Brain disorders induced by cytomegalovirus.
نویسندگان
چکیده
منابع مشابه
Cytomegalovirus infection in brain tumors
Emerging evidence demonstrate a high prevalence of cytomegalovirus (CMV) proteins and nucleic acids in different tumors. CMV is confined to tumor cells and non-cancer cells in close proximity to tumors are consistently virus negative. CMV confers both oncogenic and oncomodulatory mechanisms, and may therefore provide a novel target in cancer treatment.
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BACKGROUND: Congenital cytomegalovirus (CMV) infection is the leading infectious cause of neurologic disabilities and sensorineural hearing loss in children. Sensorineural hearing loss prevalence in CMV suggests a viral tropism for the inner ear. Vestibular disorders induced by CMV infection are underestimated. This is the largest and most thorough study to assess the incidence of vestibular di...
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In vitro lymphocyte reactivity (LR) to cytomegalovirus (CMV)-infected human fetal fibroblasts (CMVFF) and cell-free CMV were measured by using lymphocytes from healthy donors. Lymphocytes from all seropositive donors were stimulated by CMVFF, whereas lymphocytes from negative donors were not. The optimal stimulator cell-to-lymphocyte ratio was in the range of 1:5 to 1:50, dependent on the virus...
متن کاملBrain disorders
Introduction All mental functioning, be it normal or abnormal, is mediated by the brain. Thus, no child and adolescent psychiatric disorder can be thought of as not being brain related. However, there is a separate category of disorders in which the structure of the brain itself is disordered or in which the basic neurological functions are altered so that normal mental functioning may not resu...
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Macrophages (M ) are activated by IFN and are important cellular targets for infection by human and murine cytomegalovirus (MCMV), making it advantageous for CMVs to block IFN -induced M differentiation. We found that MCMV infection inhibited IFN regulation of many genes in M . MCMV infection blocked IFN responses at the level of transcription without blocking Janus kinase signal transducer and...
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ژورنال
عنوان ژورنال: Uirusu
سال: 1996
ISSN: 0042-6857,1884-3433
DOI: 10.2222/jsv.46.169